Advanced age is the leading cause for many of chronic diseases, including arthritis, atherosclerosis and cancer. Aging, which involves the accumulation of molecular and cellular damage throughout the lifespan on the organism, often leads to frailty and tissue dysfunction. Recent work demonstrates that age-related pathologies are, in part, due of the presence of senescent cells in tissue. Cellular senescence is state of growth arrest that occurs with mitotic cells in response to genomic instability or oncogenic stress. Senescence, however, promotes the secretion of a wide array of cytokines, chemokines, growth factors and proteases that may disrupt tissue function and promote the remodeling of tissue microenvironment and tumorigenicity. Our research aims understand the complex interplay among senescence, aging and cancer.