Multiple postdoctoral positions are available to study the role of the synergistic mechanism of Interleukin 6 and 8 in cell density-dependent mechanisms that govern metastasis in the Department of Chemical and Biomolecular Engineering, Johns Hopkins University, Baltimore, MD.
Proliferation and migration are two key drivers of metastasis that can be mechanistically coupled in the tumor microenvironment through local tumor cell density via the synergistic signaling of Interleukin 6 and 8. Inhibition of this mechanism in pre-clinical mouse models has demonstrated a decrease in metastatic burden to the lungs, liver, and lymph nodes. We are now further delineating this signaling mechanism to develop better therapeutics against cancer metastasis.
Please see our recent publications and webpage for detail: https://wirtzlab.johnshopkins.edu/
Competitive Salary and excellent work environment are offered. Self-motivated individuals with an advanced degree in any area of biomedical sciences and specially those who are skilled in immunobiology or bioinformatics are encouraged to apply. Please send CV and names of three references to:
Denis Wirtz PhD.
Vice Provost for Research
TH Smoot Professor, Chemical and Biomolecular Engineering, Pathology, Oncology
Director Johns Hopkins Physical Sciences-Oncology Center
Johns Hopkins University and Johns Hopkins School of Medicine
3400 N. Charles St.
Baltimore, MD 21218