#PDFTitleAuthorsJournalYear
276AcceptedMethods to analyze cell migration data​: Fundamentals and practical guidelinesP.-H. Wu, J.M. Phillip, W. Du, A. Forjaz, P.R. Nair, and D. WirtzNature MethodsAccepted (2025)
275AcceptedSelecting the optimal cell migration assay: Fundamentals and practical guidelinesW. Du, P.R. Nair, A. Forjaz, J.M. Phillip P.-H. Wu, and D. WirtzNature MethodsAccepted (2025)
274AcceptedTowards a holistic 3D tumor atlas for discoveries in cancer biology and clinical practiceM. Liu, A. Forjaz, J. Villazon, X. Tian, S. Wang, L. Shi, R. Fan*, D. Wirtz*, A. Kiemen*Nature Reviews Cancer2025
273AcceptedA disrupted compartment boundary underlies abnormal cardiac patterning and congenital heart defectsI.S. Kathiriya, M.H. Dominguez, K.S. Rao, J.M. Muncie-Vasic, W.P. Devine, K.M. Hu, S.K. Hota, B.I. Garay, D. Quintero, P. Goyal, M.N. Matthews, R. Thomas, T. Sukonnik, D. Miguel-Perez, S. Winchester, E.F. Brower, A. Forjaz, P.H. Wu, D. Wirtz, A.L. Kiemen, and B.J. BruneauNature Cardiovascular Research2025
272pdfSenescent cell heterogeneity and responses to senolytic treatment are related to cell cycle status during cell growth arrestF. Neri, S. Zheng, M. Watson, P.-Y. Desprez, A.A. Gerencser, J. Campisi, D. Wirtz*, P.-H. Wu*, B. Schilling*Aging2025
271pdfMechano-induced homotypic patterned domain formation by monocytesW. Du, J. Zhu, Y. Wu, H. Liu, A.L. Kiemen, Z. Wan, E.A. Hanna, H. Zhang, S.X. Sun, and D. WirtzNature Materials2025
270pdfHuman interpretable grammar encodes multicellular systems biology models to democratize virtual cell laboratoriesJ.A.I. Johnson, D.R. Bergman, H.L. Rocha, D.L. Zhou, E. Cramer, I.C. Mclean, Y.W. Dance, M. Booth, Z. Nicholas, T. Lopez-Vidal, A. Deshpande, R. Heiland, E. Bucher, F. Shojaeian, M. Dunworth, A. Forjaz, M. Getz, I. Godet, F. Kurtoglu, M. Lyman, J. Metzcar, J.T. Mitchell, A. Raddatz, J. Solorzano, A. Sundus, Y. Wang, D.G. DeNardo, A.J. Ewald, D.M. Gilkes, L.T. Kagohara, A.L. Kiemen, E.D. Thompson, D. Wirtz, L.D. Wood, P.-H. Wu, N. Zaidi, L. Zheng, J.W. Zimmerman, J.M. Phillip, E.M. Jaffee, J.W. Gray, L.M. Coussens, Y.H. Chang, L.M. Heiser, G.L. Stein-O’Brien, E.J. Fertig, and P. MacklinCell2025
269pdfSpatial proteomics and transcriptomics reveal early immune Cell organization in pancreatic intraepithelial neoplasiaM.R. Lyman, J.T. Mitchell, S. Raghavan, L.T. Kagohara, A.L. Huff, S.D. Haldar, S.M. Shin, S. Guinn, B. Barrett, G. Longway, A. Hernandez, E.M. Coyne, X. Yuan, L. Andaloori, J. Lai, Y.Z. Liu, R. Karchin, A. Gupta, A.L. Kiemen, A. Forjaz, D. Wirtz, P.-H. Wu, A. Deshpande, J.W. Lee, T.D. Armstrong, N.S. Azad, J.W. Zimmerman, L.D. Wood, R.A. Anders, E.D. Thompson, E.M. Jaffee, E.J. Fertig, W.J. Ho, and N. ZaidiJournal of Clinical Investigation Insight2025
268pdfThree-dimensional assessments are necessary to determine the true, spatially resolved composition of tissuesA. Forjaz, E. Vaz, V.M. Romero, S. Joshi, A. M. Braxton, A. C. Jiang, K. Fujikura, T. Cornish, S.-M. Hong, R. H. Hruban, P.-H. Wu, L. D. Wood, A. L. Kiemen, and D. WirtzCell Reports Methods2025
267pdfInterpolAI: deep learning-based optical flow interpolation and restoration of biomedical images for improved 3D tissue mappingS. Joshi, A. Forjaz, K.S. Han, Y. Shen, V. Queiroga, F.A. Selaru, M. Gérard, D. Xenes, J. Matelsky, B. Wester, A.M. Barrutia, A.L. Kiemen, P.H. Wu, and D. WirtzNature Methods2025
266pdfDevelopment of a method for visualizing and quantifying thrombus formation in extracorporeal membrane oxygenatorsJ.S.H. Wang, A.A. Rodolf, C.H. Moon, A. Lauthner, H.H. Vu, S. Rugonyi, A.J. Hansen, H.M. Mayes, B. Zakhary, D. Zonies, R. Ran, A. Khan, D. Wirtz, A.L. Kiemen, O.J.T. McCarty, and J.J. ShatzelCellular and Molecular Engineering2025
265pdfUnifying fragmented perspectives with additive deep learning for high-dimensional models from partial faceted datasetsY. Wu, P. H. Wu, A. Chambliss, D. Wirtz, & S. X. Sunnpj Biological Physics and Mechanics2025
264pdfLocal, sustained and targeted co-delivery of MEK inhibitor and doxorubicin inhibits tumor progression in E-cadherin positive breast cancerP.M. Kuhn, G.C. Russo, A.J. Crawford, A. Venkatraman, N. Yang, B.A. Starich, Z. Schneiderman, P.-H. Wu, T. Vo, D. Wirtz*, and E. Kokkoli*Pharmaceutics2024
263pdfPanIN and CAF Transitions in pancreatic carcinogenesis revealed with spatial data integrationA.T.F. Bell, J.T. Mitchell, A.L. Kiemen, K. Fujikura, H. Fedor, B. Gambichler, A. Deshpande, P.-H. Wu, D.N. Sidiropoulos, R. Erbe, J. Stern, R. Chan, S. Williams, J.M. Chell, J.W. Zimmerman, D. Wirtz, E.M. Jaffee, L.D. Wood, E. J. Fertig, L. T. KagoharaCell Systems2024
262pdfMechanotransductive feedback control of endothelial cell motility and vascular morphogenesisD.E. Mason, P. Chamacho, M.E. Goeckel, B.R. Tobin, S.L. Vega, P.-H. Wu, D. Johnson, S.-J. Heo, D. Wirtz, J.A. Burdick, L. Wood, B.Y. Chow, A.N. Stratman, and J.D. BoerckeleLife2024
261pdfCombined assembloid modeling and 3D whole-organ mapping captures the microanatomy and function of the human fallopian tubeA.J. Crawford, A. Forjaz, I. Bhorkar, T. Roy, D. Schell, V. Queiroga, K. Ren, D. Kramer, J. Bons, W. Huang, G.C. Russo, M.-H. Lee, B. Schilling, P.-H. Wu, I.-M. Shih, T.-L. Wang, A. Kiemen, and D. WirtzScience Advances2024
260pdfAge-related increases in IGFBP2 increase melanoma cell invasion and lipid synthesisG.M. Alicea, M.E. Portuallo, P. Patel, M.E. Fane, A. Carey, D.W. Speicher, A. Kossenkov, V. W. Rebecca III, D. Wirtz, and A.T. WeeraratnaCancer Research Communications2024
259pdf
PanIN or IPMN? Redefining lesion size in 3 dimensionsA.L. Kiemen, L. Dequiedt, Y. Shen, Y. Zhu, V. Matos-Romero, A. Forjaz, K. Campbell, W. Dhana, T. Cornish, A. Braxton, P.-H. Wu, E.K. Fishman, L.D. Wood, D. Wirtz, and R.H. HrubanThe American Journal of Surgical Pathology2024
258pdfPower-law growth models explain incidences and sizes of pancreatic cancer precursor lesions and confirm spatial genomic findingsA.L. Kiemen, P.-H. Wu, A.M. Braxton, T.C. Cornish, R.H. Hruban, L.D. Wood, D. Wirtz, D. ZwickerScience Advances2024
257pdf
Small extracellular vesicles promote stiffness-mediated metastasisA. Sneider, Y. Liu, B. Starich, W. Du, P. Nair, C. Marar, N. Faqih, G.E. Ciotti, J. HoKim, S. Krishnan, S. Ibrahim, M. Igboko, A.Locke, D.M. Lewis, H. Hong, M. Karl, R. Vij, G.C. Russo, E. Gómez-de-Mariscal, M. Habibi, A. Muñoz-Barrutia, L. Gu, T.S.K. Eisinger-Mathason, and D. WirtzCancer Research Communications2024
256pdf
E-cadherin interacts with EGFR resulting in hyper-activation of ERK in multiple models of breast cancerG. Russo, A. Crawford, D. Clark, J. Cui, R. Carney, M.N. Karl, B. Su, B. Starich, T.S. Lih, P. Kamat, Q. Zhang, P.R. Nair, P.- H. Wu, M.H. Lee, H.S. Leong, V.W. Rebecca H. Zhang, and D. WirtzOncogene2024
255pdf3D genomic mapping reveals multifocality of human pancreatic precancers A.M. Braxton, A.L. Kiemen, M.P. Grahn, A. Forjaz, J. Parksong, J.M. Babu, J. Lai, L. Zheng, N. Niknafs, L. Jiang, H. Cheng, Q. Song, R. Reichel, S. Graham, A.I. Damanakis, C.G. Fischer, S. Mou, C. Metz, J. Granger, X.-D. Liu, N. Bachmann, Y. Zhu, Y.Z. Liu, C. Almagro-Pérez, A.C. Jiang, J. Yoo, B. Kim, S. Du, E. Foster, J.Y. Hsu, P.A. Rivera, L.C. Chu, D. Liu, E.K. Fishman, A. Yuille, N.J. Roberts, E.D. Thompson, R.B. Scharpf, T.C. Cornish, Y. Jiao, R. Karchin, R.H. Hruban, P.-H. Wu, D. Wirtz*, and L.D. Wood*Nature2024
254pdfHigh-resolution 3D printing of pancreatic ductal microanatomy enabled by serial histology A.L. Kiemen, A. Forjaz, R. Sousa, K. Sang Han, R.H. Hruban, L.D. Wood, P.H. Wu, and D. WirtzAdvanced Materials Technologies 2024
253pdfMLL1 regulates cytokine-driven cell migration and metastasisP.R. Nair, L. Danilova, E. Gómez-de-Mariscal, D. Kim, R. Fan, A. Muñoz-Barrutia, E.J. Fertig, and D. WirtzScience Advances2024
252pdfMagnetic resonance imaging–based assessment of pancreatic fat strongly correlates with histology-based assessment of pancreas compositionA. L. Kiemen, M. Dbouk, E.A. Diwan, A. Forjaz, L. Dequiedt, A. Baghdadi, S.P. Madani, M.P. Grahn, C. Jones, S.Vedula, P.-H. Wu, D. Wirtz, S. Kern, M. Goggins, R.H. Hruban, I.R. Kamel, and M.I. CantoPancreas2024
251pdfTumor proliferation and invasion are intrinsically coupled and unraveled through tunable spheroid and physics-based modelsA.J. Crawford, C. Gomez-Cruz, G.C. Russo, W. Huang, I. Bhorkar, T. Roy, Arrate Muñoz-Barrutia, D. Wirtz, and D. Garcia-GonzalezActa Biomateralia2024
250pdfThree‑dimensional analysis of ductular reactions and their correlation
with liver regeneration and fbrosis
T. Yoshizawa, J. W. Lee, S.-M. Hong, D.J. Jung, M. Noe, W. Sbijewski, A. Kiemen, P.H, Wu, D. Wirtz, R.H. Hruban, L.D. Wood, and K. OshimaVirchows Archiv 2023
249pdfUncovering the spatial landscape of molecular interactions within the tumor microenvironment through latent spacesA. Deshpande, M. Loth, D.N. Sidiropoulos, S. Zhang, L. Yuan, T.T.F. Bell, Q. Zhu, Won Jin Ho, C. Santa-Maria, D.M. Gilkes, S.R. Williams, C.R. Uytingco, J. Chew, A. Hartnett, Z.W. Bent, A.V. Favorov, A.S. Popel, M. Yarchoan, A. Kiemen, P.-H. Wu, K. Fujikura, D. Wirtz, L.D. Wood, L. Zheng, E.M. Jaffee, R.A. Anders, L. Danilova, G. Stein-O’Brien, L.T. Kagohara, and E.J. FertigCell Systems2023
248pdfIntraparenchymal metastases as a cause for local recurrence of pancreatic cancer A. L. Kiemen, Y. Choi, A. M. Braxton, C. Almagro Perez, S. Graham, M. P. Grahn, N. Nanda, N. Roberts, L. WoodHistopathology2023
247pdfMulti-compartment organoidsM.-H. Lee, G. C. Russo, Y. S. Rahmanto, W. Du, A. J. Crawford, P.-H. Wu, D. Gilkes, A. Kiemen, T. Miyamoto, Y. Yu, M. Habibi, I.-M. Shih, T.-L. Wang, D. WirtzMaterials Today2022
246pdfTissue clearing and 3D reconstruction
of digitized, serially sectioned slides
provide novel insights into pancreatic cancer
A.L. Kiemen, A.I. Damanakis, A.M. Braxton, J. He, D. Laheru, E.K. Fishman, P. Chames, C. Almagro Perez, P.-H. Wu, D. Wirtz, L.D. Wood, and R. HrubanMed2022
245pdfCODA: quantitative 3D reconstruction of large tissues at cellular resolutionA.L. Kiemen, A.M. Braxton, M.P. Grahn, K.S. Han, J.M. Babu, R. Reichel, A.C. Jiang, B. Kim, J. Hsu, F. Amoa, S. Reddy, S.-M. Hong, T.C. Cornish, E.D. Thompson, P. Huang, L.D. Wood, R.H. Hruban, D. Wirtz and P.H. WuNature Methods2022
244pdfLung Cancer Recurrence Risk Prediction through Integrated Deep Learning EvaluationP. Huang, P. B. Illei, W. Franklin, P-H. Wu, P. M. Forde, S. Ashrafinia, C. Hu, H. Khan, H. V. Vadvala, I-M. Shih, R. J. Battafarano, M. A. Jacobs, X. Kong, J. Lewis, R. Yan, Y. Chen, F. Housseau, A. Rahmim, E. K. Fishman, D. S. Ettinger, K. J. Pienta, D. Wirtz, M. V. Brock, S. Lam, E. Gabrielson Cancers2022
243pdfEngineered bispecific antibodies targeting the interleukin-6 and -8 receptors potently inhibit cancer cell migration and tumor metastasis H. Yang*, M.N. Karl*, W. Wang, B. Starich, H. Tan, A. Kiemen, A.B. Pucsek, Y.-H. Kuo, G.C. Russo, T. Pan, E.M. Jaffee, E.J. Fertig, D. Wirtz, J.B. Spangler
* indicates co-first author
Molecular Therapy2022
242pdfCell Trafficking at the
Intersection of the
Tumor–Immune
Compartments
W. Du, P. Nair, A. Johnston, P.-H. Wu, D. WirtzAnnual Review of Biomedical Engineering2022
241pdfDeep Learning Identification of Stiffness Markers in Breast CancerA. Sneider*, A. Kiemen*, J. H. Kim, P.H. Wu, M. Habibi, M. White, J. M. Phillip, L. Gu, D. Wirtz
* indicates co-first author
Biomaterials2022
240pdfUse of the p-value as a size-dependent function to address practical differences when analyzing large datasets E. Gomez-de-Mariscal, V. Guerrero, A. Sneider, H. Jayatilaka, J. M. Phillip, D. Wirtz, A. Munoz-BarrutiaScientific Reports2021
239pdfMechanical tension mobilizes Lgr6+ epidermal stem cells to drive skin growthY. Xue, C. Lyu,A. Taylor, A. Van Ee, A. Kiemen, Y.G Choi, N. Khavanian, D. Henn, C. Lee, L. Hwang, E. Wier, S. Wang, S. Lee, A. Li, C. Kirby, G. Wang, P.H. Wu, D. Wirtz, L. A. Garza, S. K. Reddy Science Advances2022
238pdfCharacterization of tumor-associated macrophages in prostate cancer transgenic mouse modelsA.E. de Groot, K.V Myers, T.E.G. Krueger, A.L. Kiemen, N.H. Nagy, A. Brame, V. Torres, Z. Zhang, L. Trabzonlu, W.N. Brennen, D. Wirtz, A.M. De Marzo, S.R. Amend, K.J. PientaThe Prostate2021
237pdfExtracellular vesicles in immunomodulation and tumor progressionC. Marar, B. Starich, and D. WirtzNature Immunology 2021
236pdfFractional re-distribution among cell motility states during ageingJ. M. Phillip, N. Zamponi, M.P. Phillip, J. Daya, S. McGovern, W. Williams, K. Tschudi, H. Jayatilaka, P.-H. Wu, J. Walston, and D. WirtzCommunications Biology2021
235pdfA robust unsupervised machine-learning method
to quantify the morphological heterogeneity of
cells and nuclei
J.M. Phillip, K.S. Han, W.C. Chen, D. Wirtz, P.H. WuNature Protocols2021
234pdfEmergency seed funding for COVID-19 research: lessons from Johns Hopkins UniversityJ. Messersmith, C. Stoddart-Osumah, M. Lennon, and D. WirtzJournal of Clinical Investigation2020
233pdfEffect of an alkyl spacer on the morphology and internalization
of MUC1 aptamer-naphthalimide amphiphiles for targeting and
imaging triple negative breast cancer cells
H. Kuang, Z. Schneiderman, A.M. Shabana, G.C. Russo, J. Guo, D. Wirtz, E. KokkoliBioengineering & Translational Medicine2020
232pdfSingle-cell volume measurements utilizing the fluorescence exclusion method (FXm)N.D Rochman, K. Yao, N.A. Perez Gonzalez, D. Wirtz, and S.X. SunBio-Protocol2020
231pdfCompleting the great unfinished symphony of cancer together: The importance of immigrants in cancer researchP.J. Morin, D. Wirtz, and A.T. WeeraratnaCancer Cell2020
230pdfDorsoventral polarity directs cell responses to migration track geometriesE.O. Wisniewski, P. Mistriotis, K. Bera, R.A. Law, J. Zhang , M. Nikolic , M. Weiger , M. Parlani , S. Tuntithavornwat , A. Afthinos, R. Zhao, D. Wirtz, P. Kalab, G. Scarcelli, P. Friedl, and K. KonstantopoulosScience Advances2020
229pdfThree-dimensional analysis of extrahepatic cholangiocarcinoma and tumor buddingT. Yoshizawa, S.-M. Hong, D. Jung, M. Noë, A. Keimen, P.-H. Wu, D. Wirtz, R.H. Hruban, L.D. Wood, and K. OshimaJournal of Pathology2020
228pdfSupramolecular design of unsymmetric reverse bolaamphiphiles for cell-sensitive hydrogel degradation and drug releaseR. W. Chakroun, A. Sneider, C. F. Anderson, F. Wang, P.-H. Wu, D. Wirtz, and H. CuiAgewandte Chemie Internaltional Ed.2020
227pdfInactivation of Arid1a in the endometrium is associated with endometrioid tumorigenesis through transcriptional reprogrammingY. S. Rahmanto, W. Shen, X. Shen, X. Chen, Y. Yu, Z.-C. Yu, T. Miyamoto, M.-H. Lee, V. Singh, R. Asaka, G. Shimberg, M. I. Vitolo, S. S. Martin, D. Wirtz, R. Drapkin, J. Xuan, T.-L. Wang, and I.-M. ShihNature Communications2020
226pdfMoving academic research forward during COVID-19N. S. Wigginton, R. M. Cunningham, R. H. Katz, M. E. Lidstrom, K. A. Moler, D. Wirtz, and M. T. ZuberScience2020
225pdfParticle-tracking microrheology of cancer cells in living subjectsP.-H. Wu, S.S. Gambhir, C.M. Hale, W.-C Chen, D. Wirtz, and B.R. SmithMaterials Today2020
224pdfSingle-cell morphology encodes metastatic potentialP.-H. Wu, D.M. Gilkes, J.M. Phillip, A. Narkar, T. Wen-Tao Cheng, J. Marchand, M.-H. Lee, R. Li, and D WirtzScience Advances2020
223pdfDynamic organelle distribution initiates actin-based spindle migration in mouse oocytesX. Duan, Y. Li, Kexi Yi, F. Guo, H. Wang, P.H. Wu, J. Yang, D. Mair, E.A. Morales, P. Kalab, D. Wirtz, S.X. Sun, and R. LiNature Communications2019
222pdfSolid stress in brain tumorsD.M. Gilkes and D. WirtzTrends in Cancer2019
221pdfThree-dimensional visualization of cleared human pancreas cancer reveals that sustained epithelial-to-mesenchymal transition is not required for venous invasionS.-M. Hong, D. Jung, A. Kiemen, M.M. Gaida, T. Yoshizawa, A.M. Braxton, M. Noë, G. Lionheart, K. Oshima, E. D. Thompson, R. Burkhart, P.-H. Wu, D. Wirtz, R.H. Hruban, and L. D. WoodModern Pathology2019
220pdfEnabling migration by moderation: YAP/TAZ are essential for
persistent migration
P. Nair, D. WirtzJournal for cell biology2019
219pdfCell tension and mechanical regulation of cell volumeN. Perez-Gonzalez, J. Tao, N.D. Rochman, D. Vig, E. Chiu, D. Wirtz, and S.X. SunMolecular Biology of the Cell2018
218pdfMechanics of the cell nucleusD.-H. Kim, J. Hah, and D. WirtzAdvances in Experimental Medicine and Biology2018
217pdfDissecting cellular mechanics: Implications for aging, cancer, and immunityM.J. Harris, D. Wirtz, and P.-H. WuSeminar in Cell and Developmental Biology2018
216pdfRecapitulation of molecular regulators of nuclear motion during cell migrationA. Sneider, J. Hah, D. Wirtz, and D-H. KimCell Adhesion and Migration2018
215pdfMetabolic and Mechanical Cues in Pluripotent Stem Cell FateT. Perestrelo, M. Correia, J. Ramalho-Santos, and D. WirtzTrends in Cell Biology2018
214pdfTumor cell density regulates matrix metalloproteinases for enhanced migrationH. Jayatilaka, F. G. Umanzor, V. Shah, T. Meirson, G. Russo, B. Starich, P. Tyle, J.S.H. Lee, S. Khatau, H. Gil-Henn and D. WirtzOncotarget2018
213pdfImmunolabeling of cleared human pancreata provides insights into three-dimensional pancreatic anatomy and pathologyM. Noë, N. Rezaee, K. Asrani, M. Skaro, V.P. Groot, P.-H. Wu, M.T. Olson, S.-M. Hong, S.J. Kim, M.J. Weiss, C.L. Wolfgang, M.A. Makary, J. He, J.L. Cameron, D. Wirtz, N.J. Roberts, G.J.A. Offerhaus, L.A.A. Brosens, L.D. Wood, and R. H. HrubanThe American Journal of Pathology2018
212pdfThe Biophyics of Cell MigrationP-H. Wu, D. Gilkes, D. WirtzAnnual Review of Biophysics2018
211pdfMulti-Nucleated Cells use ROS to Induce Breast Cancer Chemoresistance
in vitro and in vivo
A. Parekh, S. Das, S. Parida, C. Kanta Das, D. Dutta, S. Mallick, P-H. Wu, B. N. Prashanth Kumar, R. Bharti, G. Dey, K. Banerjee, S. Rajput, D. Bharadwaj, I. Pal, K. kumar Dey, Y. Rajesh, B. Chandra Jena, A. Biswas, P. Banik, A. Pradhan, S. Das, A. Kumar Das, S. Dhara, P. Fisher, D. Wirtz, G. Mills, M. MandalOncogene2018
210pdfInhibition of Ovarian Tumor Cell Invasiveness by Targeting SYK in the Tyrosine Kinase Signaling PathwayY. Yu, Y. Suryo Rahmanto, M-H. Lee, P-H. Wu, J. Phillip, C-H. Huang, M. Vitolo, S. Gaillard, S. Martin, D. Wirtz, I-M. Shih, T-L. WangOncogene2018
209pdfA Comparison of Cethods to Assess Cell Mechanical PropertiesP-H. Wu, D. Raz-Ben Aroush, A. Asnacios, W-Ch. Chen, M. Dokukin,
B. Doss, P. Durand-Smet, A. Ekpenyong, J. Guck, N. Guz, P. Janmey, J. Lee, N. Moore, A. Ott, Y-C. Poh, R. Ros, M. Sander, I. Sokolov, J. Staunton, N. Wang, G. Whyte, and D. Wirtz
Nature Methods2018
208pdfIsomeric Control of the mechanical properties of supramolecular filament hydrogelsY‐A. Lin, M. Kang, W.‐C. Chen, Y.‐C. Ou, A.G. Cheetham, P.‐ H. Wu, D. Wirtz, S.M. Loverde, and H. CuiBiomaterials Science2018
207pdfRole of Membrane-tension Gated Ca Flux in Cell MechanosensationLijuan He, Jiaxiang Tao, Fangwei Si, Yi Wu, Tiffany Wu, Vishnu Prasath,
Denis Wirtz, and Sean X. Sun
Journal of Cell Science2018
206pdfLoss of giant obscurins alters breast epithelial cell mechanosensing of matrix stiffnessK.M. Stroka, B.S. Wong, J.M.P. Marey Shriver, D. Wirtz, A. Kontrogianni-Konstantopoulos, K. KonstantopoulosOncotarget2017
205pdfNuclear lamin A/C harnesses the perinuclear apical actin cables to protect nuclear morphologyJ.-K. Kim, A. Louhghalam, G. Lee, B.W. Schafer, D. Wirtz, and D.H. KimNature Communications2017
204pdfGoing with the flow: Water flux and cell shape during cytokinesisY. Li, L. He, N.A.P. Gonzalez, J. Graham, C. Wolgemuth, D. Wirtz, and S.X. SunBiophysical Journal2017
203pdfCancer protrusions on a tightrope: Nanofiber curvature contrast quantitates single protrusion dynamicsB. Koons, P. Sharma, Z. Ye, A. Mukherjee, M.H. Lee, D. Wirtz, B. Behkam, A. Singh NainACS Nano2017
202pdfEB1 and cytoplasmic dynein mediate protrusion dynamics for efficient three-dimensional cell migrationH. Jayatilaka, A. Giri, M. Karl, I. Aifuwa, N.J. Trenton, J.M. Phillip, Shyam Khatau, and Denis WirtzFASEB Journal2017
201pdfComparative study of cell mechanics methodsP.-H. Wu, D. Raz-Ben Aroush, A. Asnacios, W.-C. Chen, M.E. Dokukin, B.L. Doss, P. Durand, A. Ekpenyong, J. Guck, N. Guz, P.A. Janmey, N.M. Moore, A. Ott, Y.-C. Poh, R. Ros, M. Sander, I. Sokolov, J.R. Staunton, N. Wang, G. Whyte, and D. WirtzNature Methods2017
200pdfBiophysical and biomolecular determination of
cellular age in humans
Jude M. Phillip, Pei-Hsun Wu, Daniele M. Gilkes, Wadsworth Williams, Shaun McGovern, Jena Daya, Jonathan Chen, Ivie Aifuwa, Jerry S. H. Lee, Rong Fan, Jeremy Walston
and Denis Wirtz
Nature Biomedical Engineering2017
199pdfHypoxia Selectively Enhances Integrin a5b1 Receptor Expression in Breast Cancer to Promote MetastasisJulia A. Ju, Ines Godet, I Chae Ye, Jungmin Byun
, Hasini Jayatilaka
, Sun Joo Lee, Lisha Xiang, Debangshu Samanta, Meng Horng Lee, Pei-Hsun Wu, Denis Wirtz, Gregg L. Semenza, and Daniele M. Gilkes
Molecular Cancer Research2017
198pdfPluri-IQ: Quantification of Embryonic Stem Cell Pluripotency through
an Image-Based Analysis Software
Tainia Perestrelo, Weitong Chen, Marcelo Correia, Christopher Le, Sandro Pereira, Ana S. Rodrigues, Maria I. Sousa, Joao Ramalho-Santos, and Denis WirtzStem Cell Reports2017
197videoMammalian cell Division in 3D matrices via quantitative confocal reflection microscopyL. He, A. Sneider, W. Chen, M. Karl, V. Prasath, P.-H. Wu, G. Mattson, and D. WirtzJournal of Visual Experiments2017
196pdfSynergistic IL-6 and IL-8 paracrine signalling pathwy infers a strategy to inhibit tumour cell migrationHasini Jayatilaka, Pranay Tyle, Jonathan J. Chen, Minsuk Kwak, Julia J u,Hyun Ji Kim, Jerry S.H. Lee, Pei-Hsun Wu, Daniele M. Gilkes, Rong Fan, Denis WirtzNature Communications2017
195pdfAffine and non-affine deformations quantified in cytoskeletal networks through three-dimensional form-finding modelY. Wang, J. Gong, D. Wirtz, and B.W. Schafer,Mechanical Behavior of Biomedical Materials2017
194 pdfModeling the Two-way Feedback Between Contractility and Matrix Realignment Reveals a Non-linear Mode of Cancer Cell InvasionH Ahmadzadeh, M R Webster, A M Jimenez Valencia, D Wirtz, A T Weeraratna, V B ShenoyProceedings of the National Academy of Sciences2017
193 pdfCutting the stress outD. M. Gilkes and D. WirtzNature Biomedical Engineering2017
192 pdfTransient Opening of the Mitochondrial Permeability Transition Pore Induces Microdomain Calcium Transients in Astrocyte ProcessesA. Agarwal, P-H Wu, E.G. Hughes, M. Fukaya, M.A. Tischfield, A. Langseth,D. Wirtz, D.E. BerglesNeuron2017
191 pdfEngineered Models of
Confined Cell Migration
C.D. Paul, W.C. Hung, D. Wirtz, K KonstantopoulosThe Annual Reviews of Biomedical Engineering2016
190 pdfConfinement-sensing and Signal Optimization via Piezo1/PKA and Myosin II pathwaysW-C. Hung, J.Wang, C. Yankaskas, B.S. Wang, P-H. Wu, C. Pardo-Pastor, S. Serra, M.J. Chiang, Z. Gu, M. Valverde, D. Wirtz, J. Yang, J. Zhang, K. Konstantopoulos

Cell Reports2016
189 pdfMMSET/WHSC1 enhances DNA damage repair leading to an increase in resistance to chemotherapeutic agentsJ. Licht, M. Shah, E. Martinez-Garcia, J. Phillip, A. Chambliss, R. Popovic, T. Ezponda, E. Small, C. Will, M. Phillip, P. Neri, N. Bahlis, and D. WirtzOncogene2016
188 pdfDifferential vesicular sorting of AMPA and
GABAA receptors
Y. Gua, S-L Chiu, B. Liua, P-H Wu, M. Delannoy, D-T Lin, D. Wirtz and R. L. HuganirProceedings of the National Academy of Sciences2016
187 pdfBiophysical changes reduce energetic demand in growth factor–deprived lymphocytesV.C. Hecht, L.B. Sullivan, R.J. Kimmerling, D.-H. Kim, A.M. Hosios, 
M.A. Stockslager, M.M. Stevens, J.H. Kang, D. Wirtz, M.G. Vander Heiden, and S.R. ManalisJournal of Cell biology2016
186 pdfEvolution of cellular morphophenotypes
in cancer metastasis
P-H.Wu, J. M. Phillip, S. B. Khatau, W-C. Chen, J. Stirman, S. Rosseel, K. Tschudi, J. V. Patten, M. Wong, S. Gupta, A. S. Baras, J. T. Leek, A. Maitra, D. WirtzScientific Reports2015
185 pdfA robust non-linear tissue-component discrimination method for computational pathologyJ. S. Sarnecki, K, H. Burns, L. D. Wood, K. M. Waters, R. H. Hruban, D. Wirtz, and P. WuLaboratory Investigation2015
184 pdfLocal 3D matrix confinement determines division axis through cell shapeL. He, W. Chen, P.-H. Wu, A. Jimenez, B.S. Wong, A. San, K. Konstantopoulos, D. WirtzOncotarget2015
183 pdfCollective cancer cell invasion induced by coordinated contractile stressesAngela M. Jimenez Valencia, Pei-Hsun Wu, Osman N. Yogurtcu, Pranay Rao, Josh DiGiacomo, Inês Godet, Lijuan He, Meng-Horng Lee, Daniele Gilkes, Sean X. Sun, Denis WirtzOncotarget2015
182 pdfSenescent stromal cells induce cancer cell migration via inhibition of RhoA/ROCK/myosin-based cell contractilityI. Aifuwa, A. Giri, N. Longe, S.H. Lee, S. S. An, D. Wirtz Oncotarget2015
181 pdfThree-dimensional matrix fiber alignment modulates cell migration and MT1-MMP utility by spatially and temporally directing protrusionsS.I. Fraley, P.-H. Wu, L. He, Y. Feng, R. Krisnamurthy, G.D. Longmore, and D. WirtzScientific Reports2015
180 pdfVolume regulation and shape bifurcation in the cell nucleusD.-H. Kim, B. Li, F. Si, J. Philip, D. Wirtz, and S.X. SunJournal of Cell Science2015
179 pdfMultiscale model for cell migration in monolayers: elastic mismatch between cells enhanced motilityB. Palmieri, Y. Bresler, D. Wirtz, and M. GrantScientific Reports2015
178 pdfNormal mammary epithelial cells promote carcinoma basement membrane invasion by inducing microtubule-rich protrusionsM.-H. Lee, P.-H. Wu, D. Gilkes, I. Aifuwa, and D. WirtzOncotarget2015
177 pdfKinetic and mechanical properties govern Mucin 16- and Podocalyxin- mediated tumor cell adhesion to E- and L-selectin in shear FlowD.J. Shea, D. Wirtz, K.J. Stebe and K. KonstantopoulosOncotarget2015
176 pdfnhibition of spleen tyrosine kinase potentiates paclitaxel-induced cytotoxicity in ovarian cancer cells by stabilizing microtubulesY. Yu, S. Gaillard, J.M. Phillip, T.-C. Huang, S.M Pinto, N.G. Tessarollo, Z. Zhang, A. Pandey, D. Wirtz, A. Ayhan, B. Davidson, T.-L. Wang, and I.-M. ShihCancer Cell2015
175 pdfThe Mechanobiology of AgingJ. M. Phillip, I. Aifuwa, J.Walston, and D. WirtzAnnual Review of Biomedical Engineering2015
174 pdfCytoskeletal tension induces the 3D polarized architecture of the nucleusD.-H. Kim, D. WirtzBiomaterials2015
173 pdfCOX-2 dependent regulation of mechanotransduction in human breast cancer cellsA.-R. Yoon, I. Stasinopoulos, J.H. Kim, H.M. Yong, O. Kilic, D. Wirtz, Z. Bhujwalla, and S.S. AnCancer Biology and Therapy2015
172 pdfStatistical analysis of cell migration in 3D using the anisotropic persistent random walk modelP.-H. Wu, A. Giri, and D. WirtzNature Protocols2015
171 pdfSwitching from protease-independent to protease-dependent cancer cellL. He and D. WirtzBiophysical Journal2015
170 pdfLocal mechanical response of cells to the controlled rotation of
magnetic nanorods
M. Castillo, R. Ebensperger, D. Wirtz, M. Walczak,
D. Hurtado, A. Celedon
Journal of Biomedical Materials2014
169 pdfHypoxia and the extracellular matrix: drivers of tumor metastasisD. Gilkes, G. Semenza, and D. WirtzNature Reviews Cancer2014
168 pdfWater permeation drives tumor cell migration in confined microenvironmentsK.M. Stroka, H. Jiang, Z. Tong, D. Wirtz, S.X. Sun, and K. KonstantopoulosCell2014
167 pdfTight coupling between nucleus and cell migration through the perinuclear actin cap D.-H. Kim, S. Cho, and D. WirtzJournal of Cell Science2014
166 pdfThree-dimensional cell migration does not follow a random walkP.-H. Wu, A. Giri, S. X. Sun, D. WirtzProceedings of the National Academy of Sciences2014
165 pdfMorphological Effects on Expression of Growth Differentiation Factor 15 (GDF15), a Marker of MetastasisK. M. A. Yong, Y. Zeng, D. Vindivich, J. M. Phillip, P.‰ÛH. Wu, D. Wirtz, R. H. GetzenbergJournal of cellular physiology2014
164 pdfHypoxia-inducible factors mediate coordinated RhoA-ROCK1 expression and signaling in breast cancer cellsD. M. Gilkes, L. Xiang, S. J. Lee, P. Chaturvedi, M. E. Hubbi, D. Wirtz, G. L .SemenzaProceedings of the National Academy of Sciences2014
163 pdfNuclear envelope in nuclear positioning and cell migrationD. Razafsky, D. Wirtz, D. HodzicAdvances in experimental medicine and biology2014
162 pdfModulation of keratocyte phenotype by collagen fibril nanoarchitecture in membranes for corneal repairQ. Guo, J. M. Phillip, S. Majumdar, P.-H. Wu, J. Chen, X. CalderÌ_n-ColÌ_n, O. Schein, B. J. Smith, M. M. Trexler, D. Wirtz, J. H. ElisseeffBiomaterials2013
161 pdfAdhesion and fusion efficiencies of human immunodeficiency virus type 1 (HIV-1) surface proteinsT. M. Dobrowsky, S. A. Rabi, R. Nedellec, B. R. Daniels, J. I. Mullins, D. E. Mosier, R. F. Siliciano, D. WirtzScientific reports2013
160 pdfThe Arp2/3 complex mediates multigeneration dendritic protrusions for efficient 3-dimensional cancer cell migrationA. Giri, S. Bajpai, N. Trenton, H. Jayatilaka, G. D. Longmore, D. WirtzThe FASEB Journal2013
159 pdfSimultaneously defining cell phenotypes, cell cycle, and chromatin modifications at single-cell resolutionA. B. Chambliss, P.-H. Wu, W. C. Chen, S. X. Sun, D. WirtzThe FASEB Journal2013
158 pdfCollagen prolyl hydroxylases are essential for breast cancer metastasisD. M. Gilkes, Pallavi Chaturvedi, S. Bajpai, C. C. Wong, H. Wei, S. Pitcairn, M. E. Hubbi, D. Wirtz, G. L. SemenzaCancer research2013
157 pdfThe multi-faceted role of the actin cap in cellular mechanosensation and mechanotransductionD.-H. Kim, A. B. Chambliss, D. WirtzSoft matter2013
156 pdfProcollagen lysyl hydroxylase 2 is essential for hypoxia-induced breast cancer metastasisD. M. Gilkes, S. Bajpai, C. C. Wong, P.C haturvedi, M. E Hubbi, D. Wirtz, G. L. SemenzaMolecular Cancer Research2013
155 pdfPredicting how cells spread and migrate: Focal adhesion size does matterD.-H. Kim, D. WirtzCell adhesion & migration2013
154 pdfA physical sciences network characterization of non-tumorigenic and metastatic cellsTPSOC NetworkScientific reports2013
153 pdfHypoxia-inducible factor 1 (HIF-1) promotes extracellular matrix remodeling under hypoxic conditions by inducing P4HA1, P4HA2, and PLOD2 expression in fibroblastsDM Gilkes, S Bajpai, P Chaturvedi, D Wirtz, GL SemenzaJournal of Biological Chemistry2013
152 pdfFocal adhesion size uniquely predicts cell migrationD.-H. Kim, D. WirtzThe FASEB Journal2013
151 pdfInterstitial Friction Greatly Impacts Membrane MechanicsD. WirtzBiophysical Journal2013
150 pdfHigh-throughput secretomic analysis of single cells to assess functional cellular heterogeneityYao Lu, Jonathan J Chen, Luye Mu, Qiong Xue, Yu Wu, Pei-Hsun Wu, Jie Li, Alexander O Vortmeyer, Kathryn Miller-Jensen, Denis Wirtz, Rong FanAnalytical chemistry2013
149 pdfDimensional control of cancer cell migrationK Konstantopoulos, PH Wu, D WirtzBiophysical Journal2013
148 pdfThe LINC-anchored actin cap connects the extracellular milieu to the nucleus for ultrafast mechanotransductionAllison B Chambliss, Shyam B Khatau, Nicholas Erdenberger, D Kyle Robinson, Didier Hodzic, Gregory D Longmore, Denis WirtzScientific reports2013
147 pdfb-Catenin Serves as a Clutch between Low and High Intercellular E-Cadherin Bond StrengthsS Bajpai, Y Feng, D Wirtz, GD LongmoreBiophysical Journal2013
146 pdfForm-Finding Model Shows How Cytoskeleton Network Stiffness Is RealizedJ Gong, D Zhang, Y Tseng, B Li, D Wirtz, BW SchaferPloS one2013
145 pdfAge-dependent stochastic models for understanding population fluctuations in continuously cultured cellsE.B. Stukalin, I. Aifuwa, J.S. Kim, D. Wirtz, S.X. SunJournal of The Royal Society Interface2013
144 pdfFunctional interplay between the cell cycle and cell phenotypesWei-Chiang Chen, Pei-Hsun Wu, Jude M Phillip, Shyam B Khatau, Jae Min Choi, Matthew R Dallas, Konstantinos Konstantopoulos, Sean X Sun, Jerry SH Lee, Didier Hodzic, D. WirtzIntegrative Biology2013
143 pdfEffect of modifying quantum dot surface charge on airway epithelial cell uptake in vitro E. Chau, J.F. Galloway, A. Nelson, P.N. Breysse, D. Wirtz, P.C. Searson, and V.K. SidhayeNanotoxicology2012
142 pdfNAC1 is an actin-binding protein that is essential for effective cytokinesis in cancer cellsK.L. Yap, S.I. Fraley, M.M. Thiaville, N. Jinawath, K. Nakayama, J.-L. Wang, T.- L. Wang, D. Wirtz, and I.-M. ShihCancer Research2012
141 pdfDistinct Kinetic and molecular requirements govern CD44 binding to hyaluronan versus fibrin(ogen)P.S. Raman, C.S. Alves, D. Wirtz, and K. KonstantopoulosBiophysical Journal2012
140 pdfActin cap associated focal adhesions and their distinct role in cellular mechanosensingD.-H. Kim, S.B. Khatau, Y. Feng, S. Walcott, S.X. Sun, G.D. Longmore, and D. WirtzScientific Reports (Nature)2012
139 pdfThe distinct roles of the nucleus and nucleus-cytoskeleton connections in three- dimensional cell migrationS.B. Khatau, R.J. Bloom, S. Bajpai, D. Razafsky, S. Zang, A. Giri, P.-H. Wu, J. Marchand, A. Celedon, C.M. Hale, S.X. Sun, D. Hodzic, and D. WirtzScientific Report (Nature)2012
138 pdfMismatch in mechanical and adhesive properties induces pulsating cancer cell migration in epithelial monolayerM.-H. Lee, P.-H. Wu, J.R. Staunton, R. Ros, G.D. Longmore, and D. WirtzBiophysical Journal2012
137 pdfThe differential formation of the LINC-mediated perinuclear actin cap in pluripotent and somatic cells) S.B. Khatau, S. Kusuma, D. Hanjaya-Putra, P. Mali, L. Cheng, J.S.H. Lee, S. Gerecht, and D. WirtzPLOS One2012
136 pdfDivergent roles of CD44 and carcinoembryonic antigen in colon carcinoma metastasisM.R. Dallas, G. Liu, W.-C. Chen, S.N. Thomas, D. Wirtz, D.L. Huso, K. KonstantopoulosFASEB Journal2012
135 pdfDimensional and temporal controls of cell migration by zyxin and binding partners in three-dimensional matrixS.I. Fraley, Y. Feng, A. Giri, G.D. Longmore, and D. WirtzNature Communications2012
134 pdfBiophysics of selectin-mediated cell‰ÛÒcell adhesionL.S.-L. Cheung, P.S. Raman, D. Wirtz and K. KonstantopoulosComprehensive biophysics2012
133 pdfBiophysics of molecular cell mechanicsD. WirtzComprehensive biophysics2012
132 pdfCell Biophysics, IntroductionD. WirtzComprehensive biophysics2012
131 pdfHigh-throughput ballistic injection nanorheology (htBIN) to measure cell mechanicsP.-H. Wu, C.M. Hale, J.S.H. Lee, Y. Tseng, and D. WirtzNature Protocols2012
130 pdfSMRT analysis of MTOC and nuclear positioning reveals the role of EB1 and LIC1 in single-cell polarizationC.M. Hale, W.-C. Chen, S.B. Khatau, B.R. Daniels, J.S.H. Lee, and D. WirtzJournal of Cell Science2011
129 pdfNucleation and decay initiation are the stiffness-sensitive phases of focal adhesion maturationS. Walcott, D.-H. Kim, D. Wirtz, S.X. SunBiophysical Journal2011
128 pdfMagnetic manipulation of nanorods in the nucleus of living cellsA. Celedon, C.M. Hale, and D. WirtzBiophysical Journal2011
127 pdfHypoxia- Inducible Factor 1 is a master regulator of breast cancer metastatic niche formationC. C. L. Wong, D. Gilkes, H. Zhang, J. Chen, H. Wei, P. Chaturvedi, S.I. Fraley, C.M. Wong U.-S. Khoo, I.O.L. Ng, D. Wirtz, and G.L. SemenzaProceedings of the National Academy of Sciences2011
126 pdfPhysics of cancer: the role of physical interactions and mechanical forces in cancer metastasisD. Wirtz, K. Konstantopoulos, and P.C. SearsonNature Reviews2011
125 pdfRecapitulating cancer cell invasion in vitroD.-H. Kim and D. WirtzProceedings of the National Academy of Sciences2011
124 pdfIntra- and extracellular microrheology of endothelial cells in a 3D matrixS.I. Fraley, C.M. Hale, R.J. Bloom, A. Celedon, J.S.H. Lee, and D. WirtzBiological and Medical Physics, Biomedical Engineering2011
123 pdfSingle molecule binding of CD44 to fibrin versus P-selectin predicts their distinct shear-dependent interactions in cancerP.S. Raman, C.S. Alves, D. Wirtz, K. KonstantopoulosJournal of Cell Science2011
122 pdfPhysical OncologyJ.S.H. Lee and D. WirtzPhysical Biology2011
121 pdfBiophysics of selectin-ligand interactions in inflammation and cancerL.S.-L. Cheung, P.S. Raman, E.M. Balzer, D. Wirtz, and K. KonstantopoulosPhysical Biology2011
120 pdfReply: reducing background fluorescence reveals adhesions in 3D matricesS. I. Fraley, Y. Feng, D. Wirtz and G.D. LongmoreNature Cell Biology2011
119 pdfTorsional mechanics of DNA are regulated by small-molecule intercalationA. Celedon, D. Wirtz, and Sean X. SunJournal of Physical Chemistry2010
118 pdfSingle-molecule analysis of cell-virus binding interactionsT.M. Dobrowsky and D. WirtzCell Signalling Reactions: Single-Molecular Kinetic Analysis2010
117 pdfThe difference in microrheology between human induced pluripotent stem (iPS) cells and human embryonic stem (hES) cellsB.R. Daniels, C.M. Hale, S.B. Khatau, S. Kusuma, T.M. Dobrowsky, S. Gerecht, and D. WirtzBiophysical Journal2010
116 pdfInterplay of RhoA and motility in the programmed spreading of daughter cells post mitosisP. Mali, D. Wirtz, and P.C. SearsonBiophysical Journal2010
115 pdfBundles from boundariesD. Wirtz and S.B. KhatauNature Materials2010
114 pdfCross-linking FtsZ polymers into coherent Z ringsA. Dajkovic, S. Pichoff, J. Lutkenhaus, and D WirtzMolecular Microbiology2010
113 pdfPEG-based hydrogels with collagen mimetic peptide-mediated and tunable physical cross-linksP.J. Stahl, N.H. Romano, D. Wirtz, and S.M. YuBiomacromolecules2010
112 pdfMEX-5 enrichment in C. elegans early embryos mediated by differential diffusionB.R. Daniels, T.M. Dobrowsky, E.M. Perkins, S.X. Sun, and D. WirtzDevelopment2010
111 pdfThe distinctive role of focal adhesion proteins in three-dimensional cell motilityS. I. Fraley, Y. Feng, D.-H. Kim, A. Celedon, G.D. Longmore, and D. WirtzNature Cell Biology2010
110 pdfOrganization of cellular receptors into a nanoscale junction during HIV-1 adhesionT.M. Dobrowsky, B.R. Daniels, R.F. Siliciano, S.X. Sun, and D. WirtzPLOS Computational Biology2010
109 pdfTriggering cell detachment from patterned electrode arrays by programmed subcellular releaseB. Wildt, D. Wirtz, and P.C. SearsonNature Protocols2010
108 pdfThe perinuclear actin cap in health and diseaseS.B. Khatau, D.-H. Kim, C.M. Hale, and D. WirtzNucleus2010
107 pdfDynamics of the bacterial intermediate filament crescentin in vitro and in vivoE. Esue, L. Ruppercht, D. WirtzPLOS One2010
106 pdfA perinuclear actin cap regulates nuclear shapeS.B. Khatau, C.M. Hale, P.J. Stewart-Hutchinson, M.S. Patel, C.L. Stewart, P.C. Searson, D. Hodzic, and D WirtzProceedings of the National Academy of Sciences2009
105 pdfResolving the role of actomyosin contractility in cell microrheologyC.M. Hale, S.X. Sun, and D. WirtzPLOS One2009
104 pdfExploiting nucleation and growth in the synthesis and electrical passivation of CdSe quantum dotsJ.F. Galloway, J. Park, K.H. Lee, D. Wirtz, and P.C. SearsonScience of Advanced Materials2009
103 pdfLoss of ë±- catenin decreases the strength of single E-cadherin bonds between human cancer cellsS. Bajpai, Y. Feng, R. Krishnamurthy, G.D. Longmore, and D. WirtzJournal of Biological Chemistry2009
102 pdfParticle tracking microrheology of living cells: principles and applicationsD. WirtzAnnual Review of Biophysics2009
101 pdfSingle molecule torque measurements using nanorods in magnetic tweezersA. Celedon, I.M. Nodelman, B. Wildt, R. Dewan, P.C. Searson, D. Wirtz, G. D. Bowman, and S.X. SunNano Letters2009
100 pdfProgrammed sub-cellular release for studying the dynamics of cell detachmentB. Wildt, D. Wirtz, and P.C. SearsonNature Methods2009
99 pdfAsymmetric enrichment of PIE-1 in the C. elegans zygote is mediated by binary counter-diffusionB.R. Daniels, E.M. Perkins, T.M. Dobrowsky, S.X. Sun, and D. WirtzJournal of Cell Biology2009
98 pdfë±-Actinin and filamin cooperatively enhance the stiffness of actin filament networksO. Esue, Y. Tseng, and D. WirtzPLOS One2009
97 pdfSelectively altering mucus rheology to "solidify" human mucus at the nanoscaleS. K. Lai, Y. Wang, R. Cone, D. Wirtz, and J. HanesPLOS One2009
96 pdfCondensation of FtsZ filaments drives bacterial cell divisionG. Lan, B.R. Daniels, T.M. Dobrowsky, D. Wirtz, and S.X. SunProceedings of the National Academy of Sciences2009
95 pdfMicro- and macrorheology of mucusS.K. Lai, Y.-Y. Wang, D. Wirtz, J. HanesAdvanced Drug Delivery Reviews2008
94 pdfSensing cytoskeletal mechanics by ballistic intracellular nanorheology (BIN) coupled with cell transfectionM.S. Thompson and D. WirtzMethods in Cell Biology2008
93 pdfLive-cell single-molecule force spectroscopyT.M. Dobrowsky, P. Panorchan, K. Konstantopoulos, and D. WirtzMethods in Cell Biology2008
92 pdfë±-Catenin mediates initial E-cadherin-dependent cell-cell recognition and subsequent bond strengtheningS. Bajpai, J. Correia, Y. Feng, J. Figueiredo, S.X. Sun, G.D. Longmore, G. Suriano, and D. WirtzProceedings of the National Academy of Sciences2008
91 pdfDysfunctional connections between the nucleus and the actin and microtubule networks in laminopathic modelsC.M. Hale, A.L. Shrestha, S.B. Khatau, P.J. Stewart-Hutchinson, L. Hernandez, C.L. Stewart, D. Hodzic, and D. WirtzBiophysical Journal2008
90 pdfThe F-actin crosslinking/bundling activity of mammalian forminsO. Esue, E.S. Harris, H.N. Higgs, and D. WirtzJournal of Molecular Biology2008
89 pdfPolymerization and bundling kinetics of FtsZ filamentsG. Lan, A. Dajkovic, D. Wirtz, and S.X. SunBiophysical Journal2008
88 pdfMapping local matrix remodeling induced by a migrating tumor cell using 3-D multiple-particle trackingR.J. Bloom, J. P. George, A. Celedon, S.X. Sun, and D. WirtzBiophysical Journal2008
87 pdfMonitoring early fusion dynamics of human immunodeficiency virus type 1 at single-molecule resolutionT.M. Dobrowsky, Y. Zhou, S.X. Sun, R.F. Siliciano, and D. WirtzJournal of Virology2008
86 pdfFibronectin fibrillogenesis regulates 3-dimensional neovessel formationX. Zhou et alGenes and Development2008
85 pdfStructural requirements for the assembly of LINC complexes and their function in cellular mechanical stiffnessP.J. Stewart-Hutchinson, C.M Hale, D. Wirtz, and D. HodzicExperimental Cell Research2008
84 pdfMinC spatially controls bacterial cytokinesis by antagonizing the scaffolding function of FtsZA. Dajkovic, G. Lan, S.X. Sun, D. Wirtz*, and J. LutkenhausCurrent Biology2008
83 pdfNuclear lamin A/C deficiency induces defects in cell mechanics, polarization and migrationJ.S.H. Lee, C.M. Hale, P. Panorchan, S.B. Khatau, J.P. George, C. L. Stewart, D. Hodzic, and D. WirtzBiophysical Journal2007
82 pdfMicro- heterogeneity and micro-rheological properties of high-viscosity oat beta-glucan solutionsJ.Y., Xu, T. Chang, G.E. Inglett, S. Kim, Y. Tseng, and D. WirtzFood Chemistry2007
81 pdfProbing cell mechanics responses to stimuli using ballistic intracellular nanorheologyP. Panorchan, J.S.H. Lee, T.P. Kole, Y. Tseng, and D. WirtzMethods in Cell Biology2007
80 pdfA direct interaction between actin and vimentin filaments mediated by the tail domain of vimentinO. Esue, A.A. Carson, Y. Tseng, and D. WirtzJournal of Biological Chemistry2006
79 pdfMicrorheology and ROCK signaling of human endothelial cells embedded in a 3D matrixP. Panorchan, J.S.H. Lee, T.P. Kole, Y. Tseng, and D. WirtzBiophysical Journal2006
78 pdfProbing single-cell micromechanics in vivo: the microrheology of C. elegans developing embryosB.R. Daniels, B.C. Masi, and D. WirtzBiophysical Journal2006
77 pdfProbing intercellular interactions between vascular endothelial cadherin pairs at single-molecule resolution and in living cellsP. Panorcham, J.P. George, and D. WirtzJournal of Molecular Biology2006
76 pdfBallistic intracellular nanorheology reveals ROCK-hard stiffening response in to fluid flowJ. S.H. Lee, P. Panorchan, C.M. Hale, S.B. Khatau, Y. Tseng, and D. WirtzJournal of Cell Science2006
75 pdfGTPase activity, structure and mechanical properties of filaments assembled from bacterial cytoskeleton protein MreBO. Esue, D. Wirtz, and Y. TsengJournal of Bacteriology2006
74 pdfSingle-molecule analysis of cadherin-mediated cell-cell adhesionP. Panorchan, M. S. Thompson, K. J. Davis, Y. Tseng, K. Konstantopoulos, and D. WirtzJournal of Cell Science2006
73 pdfMechanics of enveloped virus entry into host cellS. X. Sun and D. WirtzBiophysical Journal2006
72 pdfMechanics and dynamics of actin-driven thin protrusionsE. Atilgan, D. Wirtz, and S. X. SunBiophysical Journal2006
71 pdfSingle- molecule analysis of HIV-1 gp120-receptor interactions in living cellsM.I. Chang, P. Panorchan, T. M. Dobrowsky, Y. Tseng, and D. WirtzJournal of Virology2005
70 pdfMorphology of the lamellipodium and the organization of actin at the leading edge of crawling cellsE. Atilgan, D. Wirtz and S. X. SunBiophysical Journal2005
69 pdfMechanical shear can accelerate the gelation of actin filament networksO. Esue, Y. Tseng, and D. WirtzPhysical Review Letters2005
68 pdfHow actin crosslinking and bundling proteins cooperate to generate an enhanced cell mechanical responseY. Tseng, T. P. Kole, J. S. H. Lee, E. Fedorov, S. C. Almo, B. W. Schafer, and D. WirtzBiochemical and Biophysical Research Communications2005
67 pdfThe rapid onset of elasticity during the assembly of the bacterial cell-division protein FtsZO. Esue, Y. Tseng, and D. WirtzBiochemical and Biophysical Research Communications2005
66 pdfCell migration without a lamellipodium: Translation of actin dynamics into cell movement mediated by tropomyosinS.L. Gupton, R.S. Fischer, T.P. Kole, A. Ponti, G. Danuser, S. E. Hitchcock- DeGregori, V.M. Fowler, D. Wirtz, D. Hanein, and C.M. Waterman-StorerJournal of Cell Biology2005
65 pdfCdc42 mediates nucleus movement and MTOC polarization in Swiss 3T3 fibroblasts under shearJ.S.H. Lee, Y. Tseng, and D. WirtzMolecular Biology of the Cell2005
64 pdfThe assembly of MreB, a prokaryotic 8 homolog of actinO. Esue, M. Cordero, Y. Tseng, and D. WirtzJournal of Biological Chemistry2005
63 pdfIntracellular mechanics of migrating fibroblastsT.P. Kole, Y. Tseng, J.L. Katz, and D. WirtzMolecular Biology of the Cell2005
62 pdfIntracellular microrheology as a tool for the measurement of the local mechanical properties of live cellsT.P. Kole, Y. Tseng, and D. WirtzMethods in Cell Biology2004
61 pdfDendritic branching and homogenization of actin network mediated by Arp2/3 complexY. Tseng and D. WirtzPhysical Review Letters2004
60 pdfStructure-function relation of biological gels revealed by multiple-particle tracking and DIC microscopy: the case of human lamin networksP. Panorchan, D. Wirtz, and Y. TsengPhysical Review2004
59 pdfNuclear envelope breakdown requires overcoming the mechanical integrity of the nuclear laminaP. Panorchan, B. W. Schafer, D. Wirtz, and Y. TsengJournal of Biological Chemistry2004
58 pdfStructure of the actin-crosslinking core of fimbrinM.G. Klein, W. Shi, Y. Tseng, D. Wirtz, D.R. Kovar, C.J. Straiger, and S.C. AlmoStructure2004
57 pdfRho kinase regulates the micromechanical response of adherent cells to Rho activationT.P. Kole, Y. Tseng, L. Huang, J.L. Katz, and D. WirtzMolecular Biology of the Cell2004
56 pdfDistinct kinetic and mechanical properties govern selectin-leukocyte interactionsW.D. Hanley, D. Wirtz, and K. KonstantopoulosJournal of Cell Science2004
55 pdfTransport of polymeric nanoparticles gene carriers in gastric mucusM. Dawson, E. Krauland, D. Wirtz, and J. HanesBiotechnology Progress2004
54 pdfMicro-organization and visco-elasticity of the nucleus revealed by particle nanotrackingY. Tseng, J.S.H. Lee, T.P. Kole, I. Jiang, and D. WirtzJournal of Cell Science2004
53 pdfTowards a regional approach to cell mechanicsS.R. Heidemann and D. WirtzTrends in Cell Biology2004
52 pdfReal-time intracellular transport phenomena of gene nanocarriers studied by multiple particle trackingJ. Suh, D. Wirtz, and J. HanesBiotechnology Progress2004
51 pdfThe bimodal role of filamin in controlling the architecture and mechanics F-actin networksY. Tseng, K.M. An, O. Esue, and D. WirtzJournal of Biological Chemistry2004
50 pdfEnhanced viscoelasticity of human cystic fibrotic sputum correlates with increasing microheterogeneity in particle transportM. Dawson, D. Wirtz, and J. HanesJournal of Biological Chemistry2003
49 pdfReceptor/ligand binding: ‰ÛÏcatch‰Û bonds finally captured experimentallyK. Konstantopoulos, W. Hanley, and D. WirtzCurrent Biology2003
48 pdfDetermining the Gaussian probability distribution of the best-fit ellipsoid of revolution for a polymer chain from planar projectionsY. Zhou, D. Wirtz, and G. ChirikjianInverse Problems2003
47 pdfThe mechanical properties of simple epithelial keratin 8 and 18: Discriminating between interfacial and bulk elasticitiesS. Yamada, D. Wirtz, and P.A. CoulombeJournal of Structural Biology2003
46 pdfSingle-molecule characterization of P-selectin/ligand bindingW. Hanley, O. McCarty, S. Jadhav, Y. Tseng, D. Wirtz, and K. KonstantopoulosJournal of Biological Chemistry2003
45 pdfA mechanism of coupling RCC1 mobility to RanGTP production on the chromatin in vivoH.Y. Li, D. Wirtz, and Y. ZhengJournal of Cell Biology2003
44 pdfEffective active transport of gene nanocarriers to the cell nucleusJ. Suh, D. Wirtz, and J. HanesProceedings of the National Academy of Sciences2003
43 pdfMicromechanical mapping of live cells by multiple particle tracking microrheologyY. Tseng, T. P. Kole, and D. WirtzBiophysical Journal2002
42 pdfLocal dynamics and viscoelastic properties of cell biological systemsY. Tseng, T. P. Kole, S.-H. J. Lee, and D. WirtzCurrent Opinion in Colloid & Interface Science2002
41 pdfEffect of length, topology, and concentration on the microviscosity and microheterogeneity of DNA solutionsA. Goodman, Y. Tseng, and D. WirtzJournal of Molecular Biology2002
40 pdfMicromechanical coupling between surface cell receptors and RGD peptidesA. Rahman, Y. Tseng, and D. WirtzBiochemical and Biophysical Research Comm.2002
39 pdfFunctional synergy of actin filament crosslinking proteinsY. Tseng, B.W. Schafer, S.C. Almo, and D. WirtzJournal of Biological Chemistry2002
38 pdfMicroheterogeneity controls the rate of gelation of actin filament networksY. Tseng, K.M. An, and D. WirtzJournal of Biological Chemistry2002
37 pdfMicroheterogeneity and microrheology of wheat gliadin suspensions studied by multiple particle trackingJ. Xu, Y. Tseng, C.J. Carriere, and D. WirtzBiomacromolecules2002
36 pdfPairwise assembly determines the intrinsic potential for self-organization and mechanical properties of keratin filamentsS. Yamada, D. Wirtz, and P.A. CoulombeMolecular Biology of the Cell2002
35 pdfThe non-helical tail domain of keratin 14 promotes filament bundling and enhances the mechanical properties of keratin intermediate filaments in vitroO. Bousquet, L. Ma, S. Yamada, C. Gu, T. Idei, K. Takahashi, D. Wirtz, and P.A. CoulombeJournal of Cell Biology2001
34 pdfMechanics and multiple particle tracking micro- heterogeneity of ë±-actinin crosslinked actin filament networksY. Tseng and D. WirtzBiophysical Journal2001
33 pdfMicromechanics and ultrastructure of actin filament networks crosslinked by fascin: A comparison with ë±-actininY. Tseng, E. Fedorov, M. McCaffery, S.C. Almo, and D. WirtzJournal of Molecular Biology2001
32 pdfA "hot-spot" mutation alters the mechanical properties of keratin filament networksL. Ma, S. Yamada, D. Wirtz, and P.A. CoulombeNature Cell Biology2001
31 pdfRheological properties of vital wheat gluten suspensionsJ. Xu, J.A. Bietz, F.C. Felker, and D. WirtzCereal Chemistry2001
30 pdfMagnetic tweezers for DNA micromanipulationC. Haber and D. WirtzReview of Scientific Instruments2000
29 pdfThe "ins" and "outs" of intermediate filament organizationP.A. Coulombe, O. Bousquet, L. Ma, S. Yamada, and D. WirtzTrends in Cell Biology2000
28 pdfStrain-hardening of actin filament networks: regulation by the dynamic crosslinking protein ë±-actininJ. Xu, Y. Tseng, and D. WirtzJournal of Biological Chemistry2000
27 pdfShape anisotropy of a single random-walk polymerC. Haber, S.A. Ruiz, and D. WirtzProceedings of the National Academy of Sciences2000
26 pdfShear-induced ëÈ-phage DNA assemblyC. Haber and D. WirtzBiophysical Journal2000
25 pdfMultiple- particle tracking measurements of the heterogeneities of solutions of actin filaments and actin bundlesJ. Apgar, Y. Tseng, E. Fedorov, M.B. Herwig, S.C. Almo, D. WirtzBiophysical Journal2000
24 pdfMechanics of living cells measured by laser tracking microrheology (LTM)S. Yamada, D. Wirtz, and S.C. KuoBiophysical Journal2000
23 pdfEpidermal keratin suspensions show unique micromechanical propertiesL. Ma, J. Xu, P.A. Coulombe, and D. WirtzJournal of Biological Chemistry1999
22 pdfDynamics of individual flexible polymers in a shear flowP. Leduc, C. Haber, G. Bao, and D. WirtzNature1999
21 pdfDiffusing wave spectroscopy microrheology of actin filament networksA. Palmer, J. Xu, S.C. Kuo, and D. WirtzBiophysical Journal1999
20 pdfHigh-frequency dynamics and microrheology of macromolecular solutions measured by diffusing wave spectroscopy: the case of actin filament networksK. Rufener, A. Palmer, J. Xu, and D. WirtzJournal of Non-Newtonian Fluid Mechanics1999
19 pdfDynamic crosslinking by ë±-actinin determines the mechanical properties of actin filament networksJ. Xu, D. Wirtz, and T.D. PollardJournal of Biological Chemistry1998
18 pdfEffect of Latrunculin A on the rheology of actin filament networksA. Palmer, B. Cha, and D. WirtzJournal of Polymer Science1998
17 pdfRheology and microrheology of semiflexible polymer solutionsJ. Xu, A. Palmer, and D. WirtzMacromolecules1998
16 pdfReversible hydrogels from self-assembling artificial proteinsW. Petka, J.H. Harden, J. McGrath, D. Wirtz, and D.A. TirrellScience1998
15 pdfDominant mode of diffusion in the self-similar phase separation of a magnetic fluidA. Silva and D. WirtzLangmuir1998
14 pdfCompliance of actin filament networks measured by diffusing wave spectroscopyJ. Xu, V. Viasnoff, and D. WirtzRheologica Acta1998
13 pdfHigh-frequency viscoelasticity of crosslinked actin filament networks measured by diffusing wave spectroscopyA. Palmer, J. Xu, and D. WirtzRheologica Acta1998
12 pdfLinear viscoelastic moduli of concentrated DNA solutionsT.G. Mason, A. Dhople, and D. WirtzMacromolecules1998
11 pdfConcentrated DNA rheology and microrheologyT.G. Mason, A. Dhople, and D. WirtzMRS Proceedings1997
10 pdfParticle-tracking microrheology of complex fluidsT.G. Mason, K. Ganesan, J. van Zanten, D. Wirtz, S.C. KuoPhysical Review Letters1997
9 pdfThe fluctuation dynamics of a single magnetic chainA. Silva, Bond, R., Plouraboue, F., and Wirtz, DPhysical Review E1996
8 pdfEnhancement of concentration fluctuations by external fieldsG.G. Fuller, J.W. van Egmond, D. Wirtz, E. Peuvrel-Didier, E. Wheeler, and H. TakahashiACS Symposium Series1995
7 pdfDirect measurement of the transport properties of a single DNA moleculeD. WirtzPhysical Review Letters1995
6 pdfPeriodic structures and substructures in magnetic suspensionsD. Wirtz and M. FermigierLangmuir1995
5 pdfOne-dimensional patterns and wavelength selection in magnetic fluidsD. Wirtz and M. FermigierPhysical Review Letters1994
4 pdfFlow-induced scattering peak in the structure factor of polymer solutionsD. WirtzPhysical Review E1994
3 pdfFluctuation enhancement and reduction in sheared polymer solutionsD. WirtzMacromolecules1994
2 pdfElectric-field-induced structure in polymer solutions near the critical pointD. Wirtz, K. Berend, and G.G. FullerMacromolecules1992
1 pdfStructure and optical anisotropies of critical polymer solutions in electric fieldsD. Wirtz, D.E. Werner, and G.G. FullerJournal of Chemical Physics1994